道格(贾斯汀.巴萨 Justin Bartha 饰)即将与女友结婚。婚礼前两天,道格与朋友菲尔(布莱德利.库珀 Bradley Cooper 饰)、西德(艾德.赫尔姆斯 Ed Helms 饰)和阿兰(扎克.加利费安纳基斯 Zach Galifianakis 饰)从洛杉矶驱车前往赌城拉斯维加斯为道格举办婚前单身派对,入住凯撒宫豪华套房。一晚过后,三人发现道格失踪,浴室里出现一只老虎,衣橱中多了一个婴儿,西德缺了一颗牙,窗外塔尖上插着席梦思床垫,菲尔戴着医院手环,西德口袋里有一张800美金收据,而他们的车也不知为何变成了警车。三人惊慌失措,完全无法记起昨晚发生过什么,却必须在24小时之内迅速解决谜团找到道格返回洛杉矶……。Two places are in focus in this soap. First of all the hospital clinic run by Göran Fridell, a doctor who can not take advice from others, including his wife Ingrid, who also works at the hospital. Their daughter Annika also works as a nurse at the hospital but dreams of becoming a doctor. She has a relationship with the young doctor Anders Ståhlberg but may loose him to nurse ...。