宗天保任职护卫员的科学园大火,他舍身救了女研究员高玉。但研究所潘教授在大火中不幸辞世,潘教授的手写笔记在大火中消失。大火引发了灰尘风暴,令整个香港被雾霾卷盖。
财阀王耀才投资的“天空一号”,让富人得以远离污染,而已故潘教授的助理唐永章变成他的合作伙伴,唐的发妻高玉继续在天空一号上钻研“超能干细胞”的“再生学”工作,完成潘教授的遗愿。从台湾来的家家带着癌症末期的妹妹小珍来香港求医,怎料两兄妹因此卷入一场“超能力干细胞”的劫案中,而偷走这新科研血清的主脑,竟是已故潘教授的独生子子文,在争夺血清的过程中,子文逐渐发现了令父亲潘教授死亡的真正凶手……。该剧为李炳宪导演首度执导的电视台播出的电视剧,也是继网剧《积极的体质》之后的又一尝试。据李炳宪导演介绍,“该剧讲述了三十多岁的女性朋友们的工作和恋爱琐碎日常”。。山田日後承認在開拍此片之前,已心諳渥美清的肺病步入末期,決定此章為最後一章,並安排由淺丘瑠璃子演的莉莉送寅次郎踏上人生的最後一程。分別15年後,兩人於如詩如畫的奄美大島重逢,感情依舊,鬥氣繼續,沒完沒了似的。正如山田所想,雖然系列必須完結,但始終不想為寅次郎的故事/人生劃上句號。結局如常開放,代表寅一直繼續他的旅程,日本人依然有夢。
公映後翌年,渥美清病逝,享年68歲,本片亦成為他的遺作。
Yamada knew before production began that Atsumi's health has deteriorated to such an extent that Tora-san to the Rescue would be the last film in the series. He decided to let Lily accompany Tora on his last trip. The lovers reunite after fifteen years in the picturesque Amami O Shima, and the affections as well as the bickering remain. Although the series must come to its conclusion, Yamada has deliberately left the film's ending open, so as not to let the curtain fall on "Tora-san". Atsumi Kiyosh passed away at the age of 68 in the year following the film's release, making this film his last.。